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J Med Case Rep. 2007 Aug 9;1:62.

Altered mental status, an unusual manifestation of early disseminated Lyme disease: A case report.

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  • 1Department of Medicine, Waterbury Hospital, Waterbury, Connecticut, USA.


Early disseminated Lyme disease can have a myriad of central nervous system manifestations. These run the gamut from meningitis to radiculopathy and cranial neuropathy. Here we present a case that manifested with only acute mental status change in the setting of central nervous system involvement with Lyme disease. A paucity of other central nervous system manifestations is rare, especially with positive serum and cerebrospinal fluid markers. This article underscores the importance of a high index of clinical suspicion in detection of Lyme disease related manifestations in endemic areas.

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