Early intervention for the ocular and neurodevelopmental sequelae of Fetal Valproate Syndrome

Zia I Carrim; Lorna McKay; Sikander S Sidiki; Timothy E Lavy

doi:10.1111/j.1440-1754.2007.01176.x

Early intervention for the ocular and neurodevelopmental sequelae of Fetal Valproate Syndrome

J Paediatr Child Health. 2007 Sep;43(9):643-5. doi: 10.1111/j.1440-1754.2007.01176.x.

Authors

Zia I Carrim¹, Lorna McKay, Sikander S Sidiki, Timothy E Lavy

Affiliation

¹ Department of Ophthalmology and Orthoptics, Southern General Hospital, and Royal Hospital for Sick Children, Glasgow, UK. zia.carrim@doctors.org.uk

PMID: 17688650
DOI: 10.1111/j.1440-1754.2007.01176.x

Abstract

The established teratogenicity of antiepileptic drugs raises important issues in women of child-bearing age. While the association between neural tube defects and antiepileptic drugs is well recognised, other congenital malformations are known to occur. We report two siblings with characteristic craniofacial features of Fetal Valproate Syndrome who also had associated ocular and neurodevelopmental problems which would benefit from early recognition and intervention.

Publication types

Case Reports

MeSH terms

Abnormalities, Drug-Induced*
Amblyopia / etiology
Anticonvulsants / administration & dosage
Anticonvulsants / adverse effects*
Autistic Disorder / etiology*
Child, Preschool
Craniofacial Abnormalities / etiology
Craniofacial Abnormalities / surgery
Epilepsy / drug therapy*
Female
Humans
Hydrocephalus / etiology
Hydrocephalus / surgery
Infant, Newborn
Male
Pregnancy
Treatment Outcome
United Kingdom
Valproic Acid / administration & dosage
Valproic Acid / adverse effects*

Substances

Anticonvulsants
Valproic Acid