Breast Cancer Res Treat. 2008 Jul;110(2):223-6. Epub 2007 Aug 9.

Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors.

Faggioli F, Soldati S, Scanziani E, Catò EM, Adorni F, Vezzoni P, Noonan DM, Sacco MG.

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Istituto di Tecnologie Biomediche, CNR, Segrate, Milan, Italy.

Abstract

Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.

PMID:: 17687642; [PubMed - indexed for MEDLINE]

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