Neurite outgrowth: a flick of the wrist

Curr Biol. 2007 Aug 7;17(15):R611-4. doi: 10.1016/j.cub.2007.05.059.

Abstract

A new study has shown that, near the tip of a growing axon, dephosphorylation of the microtubule-associated protein Doublecortin is controlled by protein phosphatase 1 and its regulator spinophilin. This results in spatially regulated microtubule bundling within the axon and more efficient axon outgrowth.

MeSH terms

  • Animals
  • Doublecortin Domain Proteins
  • Mice
  • Microtubule-Associated Proteins / metabolism
  • Microtubules / metabolism
  • Neurites / metabolism*
  • Neuropeptides / metabolism
  • Phosphorylation

Substances

  • Doublecortin Domain Proteins
  • Microtubule-Associated Proteins
  • Neuropeptides