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1: Genome Biol. 2007;8(8):R160.Click here to read Click here to read Links

Network motif analysis of a multi-mode genetic-interaction network.

Taylor RJ, Siegel AF, Galitski T.

Institute for Systems Biology, N. 34th Street, Seattle, WA 98103 USA. jtaylor@systemsbiology.org

Different modes of genetic interaction indicate different functional relationships between genes. The extraction of biological information from dense multi-mode genetic-interaction networks demands appropriate statistical and computational methods. We developed such methods and implemented them in open-source software. Motifs extracted from multi-mode genetic-interaction networks form functional subnetworks, highlight genes dominating these subnetworks, and reveal genetic reflections of the underlying biochemical system.

PMID: 17683534 [PubMed - indexed for MEDLINE]

PMCID: PMC2374991