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Cell Metab. 2007 Aug;6(2):99-104.

A balance of lipid-sensing mechanisms in the brain and liver.

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  • 1Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada.

Abstract

Recent work has cast a spotlight on the brain as a nutrient-sensing organ that regulates the body's metabolic processes. Here we discuss the physiological and molecular mechanisms of brain lipid sensing and compare these mechanisms to liver lipid sensing. A direct comparison between the lipid-sensing mechanisms in the brain and liver reveals similar biochemical/molecular but opposing physiological mechanisms in operation. We propose that an imbalance between the lipid-sensing mechanisms in the brain and liver may contribute to obesity-associated type 2 diabetes.

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