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Indian J Med Sci. 2007 Aug;61(8):471-3.

Idiopathic purpura fulminans in dengue hemorrhagic fever.

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  • 1Lady Ridgeway Hospital for Children, Colombo 8, Sri Lanka.


Purpura fulminans is a rapidly progressive thrombotic disease that has been described during both severe bacterial and viral infections. Disseminated intravascular coagulation (DIC), antiphospholipid antibodies and acquired or congenital C and S protein deficiency are thought to play a role in its pathogenesis. Here we report the case of a 4-year-old girl who developed gangrene of all her fingers and toes following dengue shock syndrome complicated by DIC and also discuss its management.

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