Viscous threads that are swept along in the flow of a less viscous miscible liquid can break up into viscous swirls. We experimentally investigate the evolution of miscible threads that flow off center in microchannels. Thin threads near the walls of a straight square channel become unstable to shear-induced disturbances. The amplification of the undulations transverse to the flow direction ultimately causes the threads to break up and form an array of individual viscous swirls, the miscible counterparts of droplets. This swirling instability provides a means for passively producing discrete diffusive microstructures in a continuous flow regime.