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Nat Struct Mol Biol. 2007 Sep;14(9):869-71. Epub 2007 Aug 5.

The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation.

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  • 1Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA.


Polycomb proteins are required for maintenance of silent chromatin states via histone H3 Lys27 trimethylation (H3K27me3) in animals, but homologs are not found in plant genomes. Using a DamID-chip method, we found that the Arabidopsis thaliana chromodomain-containing protein LHP1 colocalizes with H3K27me3 genome-wide. The LHP1 chromodomain also binds H3K27me3 with high affinity, suggesting that LHP1 has functions similar to those of Polycomb.

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