- Comment in:
-
Nat Immunol. 2007 Sep;8(9):903-5.
Development, cytokine profile and function of human interleukin 17-producing helper T cells.
Wilson NJ,
Boniface K,
Chan JR,
McKenzie BS,
Blumenschein WM,
Mattson JD,
Basham B,
Smith K,
Chen T,
Morel F,
Lecron JC,
Kastelein RA,
Cua DJ,
McClanahan TK,
Bowman EP,
de Waal Malefyt R.
Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, California 94304-1104, USA.
T(H)-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the T(H)-17 lineage is dependent on transforming growth factor-beta and interleukin 6 (IL-6). Here we demonstrate that IL-23 and IL-1beta induced the development of human T(H)-17 cells expressing IL-17A, IL-17F, IL-22, IL-26, interferon-gamma, the chemokine CCL20 and transcription factor RORgammat. In situ, T(H)-17 cells were identified by expression of the IL-23 receptor and the memory T cell marker CD45RO. Psoriatic skin lesions contained IL-23-producing dendritic cells and were enriched in the cytokines produced by human T(H)-17 cells that promote the production of antimicrobial peptides in human keratinocytes. Our data collectively indicate that human and mouse T(H)-17 cells require distinct factors during differentiation and that human T(H)-17 cells may regulate innate immunity in epithelial cells.
PMID: 17676044 [PubMed - indexed for MEDLINE]