Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt 8):653-6. Epub 2007 Jul 28.

A structural insight into lead neurotoxicity and calmodulin activation by heavy metals.

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Department of Biochemistry, University of Oulu, Oulu, Finland. petri.kursula@oulu.fi

Abstract

Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans.

PMID:: 17671360; [PubMed - indexed for MEDLINE]
PMCID:: PMC2335165

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Structures reported by this article

Recombinant Vertebrate Calmodulin Complexed With Ba

PDB: 2V02

Source: Homo sapiens

Method: X-Ray Diffraction

Resolution: 2.2 Å

See all 2 structures...

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