Expert Rev Vaccines. 2007 Aug;6(4):591-603.

Design and development of synthetic peptide vaccines: past, present and future.

Bijker MS, Melief CJ, Offringa R, van der Burg SH.

Source

Leiden University Medical Center, Department of Immunohematology, Leiden, The Netherlands. matijnbijker@yahoo.com

Abstract

Synthetic peptide vaccines aiming at the induction of a protective CD8(+) T-cell response against infectious or malignant diseases are widely used in the clinic but, despite their success in animal models, they do not yet live up to their promise in humans. This review assesses the development of synthetic peptide vaccines, weighs it against the immunological concepts that have emerged, and identifies the key issues that play a role in the failure or success of a synthetic peptide vaccine. The current state-of-the-art peptide vaccine is a complete synthetic inflammatory product that is ingested by professional antigen-presenting cells and stimulates both CD4(+) and CD8(+) T cells.

PMID:: 17669012; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine. [Clin Cancer Res. 2008]
Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine.
Welters MJ, Kenter GG, Piersma SJ, Vloon AP, Löwik MJ, Berends-van der Meer DM, Drijfhout JW, Valentijn AR, Wafelman AR, Oostendorp J, et al. Clin Cancer Res. 2008 Jan 1; 14(1):178-87.
Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells. [Clin Cancer Res. 2007]
Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells.
May RJ, Dao T, Pinilla-Ibarz J, Korontsvit T, Zakhaleva V, Zhang RH, Maslak P, Scheinberg DA. Clin Cancer Res. 2007 Aug 1; 13(15 Pt 1):4547-55.
Priming with SARS CoV S DNA and boosting with SARS CoV S epitopes specific for CD4+ and CD8+ T cells promote cellular immune responses. [Vaccine. 2007]
Priming with SARS CoV S DNA and boosting with SARS CoV S epitopes specific for CD4+ and CD8+ T cells promote cellular immune responses.
Huang J, Cao Y, Du J, Bu X, Ma R, Wu C. Vaccine. 2007 Sep 28; 25(39-40):6981-91. Epub 2007 Jul 16.
Review Mass spectrometry and peptide-based vaccine development. [Clin Pharmacol Ther. 2007]
Review Mass spectrometry and peptide-based vaccine development.
Ovsyannikova IG, Johnson KL, Bergen HR 3rd, Poland GA. Clin Pharmacol Ther. 2007 Dec; 82(6):644-52. Epub 2007 Oct 31.
Review T-cell immunity generated by recombinant adenovirus vaccines. [Expert Rev Vaccines. 2007]
Review T-cell immunity generated by recombinant adenovirus vaccines.
Yang TC, Millar JB, Grinshtein N, Bassett J, Finn J, Bramson JL. Expert Rev Vaccines. 2007 Jun; 6(3):347-56.

See reviews... See all...

Cited by 9 PubMed Central articles

Prevention and therapy of hepatocellular carcinoma by vaccination with TM4SF5 epitope-CpG-DNA-liposome complex without carriers. [PLoS One. 2012]
Prevention and therapy of hepatocellular carcinoma by vaccination with TM4SF5 epitope-CpG-DNA-liposome complex without carriers.
Kwon S, Kim D, Park BK, Cho S, Kim KD, Kim YE, Park CS, Ahn HJ, Seo JN, Choi KC, et al. PLoS One. 2012; 7(3):e33121. Epub 2012 Mar 12.
Review Current immunotherapeutic approaches in pancreatic cancer. [Clin Dev Immunol. 2011]
Review Current immunotherapeutic approaches in pancreatic cancer.
Koido S, Homma S, Takahara A, Namiki Y, Tsukinaga S, Mitobe J, Odahara S, Yukawa T, Matsudaira H, Nagatsuma K, et al. Clin Dev Immunol. 2011; 2011:267539. Epub 2011 Sep 14.
Production of antibodies with peptide-CpG-DNA-liposome complex without carriers. [BMC Immunol. 2011]
Production of antibodies with peptide-CpG-DNA-liposome complex without carriers.
Kim D, Kwon S, Rhee JW, Kim KD, Kim YE, Park CS, Choi MJ, Suh JG, Kim DS, Lee Y, et al. BMC Immunol. 2011 May 18; 12:29. Epub 2011 May 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Design and development of synthetic peptide vaccines: past, present and future.
Design and development of synthetic peptide vaccines: past, present and future.
Expert Rev Vaccines. 2007 Aug ;6(4):591-603.

PubMed
Hepatitis C treatment in "difficult-to-treat" psychiatric patients with pegylate...
Hepatitis C treatment in "difficult-to-treat" psychiatric patients with pegylated interferon-alpha and ribavirin: response and psychiatric side effects.
Hepatology. 2007 Oct ;46(4):991-8.

PubMed
Three-year immune reconstitution in PI-sparing and PI-containing antiretroviral ...
Three-year immune reconstitution in PI-sparing and PI-containing antiretroviral regimens in advanced HIV-1 disease.
Antivir Ther. 2007 ;12(4):553-8.

PubMed
Mitochondrial DNA diversity and population differentiation in southern East Asia...
Mitochondrial DNA diversity and population differentiation in southern East Asia.
Am J Phys Anthropol. 2007 Dec ;134(4):481-8.

PubMed
Type 2 diabetes whole-genome association study in four populations: the DiaGen c...
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
Am J Hum Genet. 2007 Aug ;81(2):338-45. Epub 2007 Jun 26 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: