Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40.

Cellular senescence: when bad things happen to good cells.

Source

Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA. jcampisi@lbl.gov

Abstract

Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing.

PMID:: 17667954; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Review Cancer, aging and cellular senescence. [In Vivo. 2000]
Review Cancer, aging and cellular senescence.
Campisi J. In Vivo. 2000 Jan-Feb; 14(1):183-8.
Review Cellular senescence and cancer treatment. [Biochim Biophys Acta. 2007]
Review Cellular senescence and cancer treatment.
Schmitt CA. Biochim Biophys Acta. 2007 Jan; 1775(1):5-20. Epub 2006 Aug 25.
Review Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. [Cell. 2005]
Review Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.
Campisi J. Cell. 2005 Feb 25; 120(4):513-22.
Review The DNA damage signaling pathway connects oncogenic stress to cellular senescence. [Cell Cycle. 2007]
Review The DNA damage signaling pathway connects oncogenic stress to cellular senescence.
Mallette FA, Ferbeyre G. Cell Cycle. 2007 Aug 1; 6(15):1831-6. Epub 2007 May 24.
Review Mitochondria damage checkpoint, aging, and cancer. [Ann N Y Acad Sci. 2006]
Review Mitochondria damage checkpoint, aging, and cancer.
Singh KK. Ann N Y Acad Sci. 2006 May; 1067:182-90.

See reviews... See all...

Cited by over 100 PubMed Central articles

Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. [Oncotarget. 2011]
Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells.
Goldberg AA, Beach A, Davies GF, Harkness TA, Leblanc A, Titorenko VI. Oncotarget. 2011 Oct; 2(10):761-82.
Deciphering the role of nuclear factor-κB in cellular senescence. [Aging (Albany NY). 2011]
Deciphering the role of nuclear factor-κB in cellular senescence.
Vaughan S, Jat PS. Aging (Albany NY). 2011 Oct; 3(10):913-9.
The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence. [PLoS One. 2011]
The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence.
Nijwening JH, Geutjes EJ, Bernards R, Beijersbergen RL. PLoS One. 2011; 6(9):e25235. Epub 2011 Sep 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cellular senescence: when bad things happen to good cells.
Cellular senescence: when bad things happen to good cells.
Nat Rev Mol Cell Biol. 2007 Sep ;8(9):729-40.

PubMed
Patterns and mechanisms of genome organization in the mouse.
Patterns and mechanisms of genome organization in the mouse.
J Exp Zool A Comp Exp Biol. 2006 Sep 1 ;305(9):683-8.

PubMed
Linking mother and child access to dental care.
Linking mother and child access to dental care.
Pediatrics. 2008 Oct ;122(4):e805-14.

PubMed
Engineering RNA for targeted siRNA delivery and medical application.
Engineering RNA for targeted siRNA delivery and medical application.
Adv Drug Deliv Rev. 2010 Apr 30 ;62(6):650-66. Epub 2010 Mar 15 .

PubMed
Treatment of ventricular tachyarrhythmias resulting from amitriptyline toxicity ...
Treatment of ventricular tachyarrhythmias resulting from amitriptyline toxicity in dogs.
J Pharmacol Exp Ther. 1984 Nov ;231(2):430-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: