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Expert Opin Biol Ther. 2007 Jul;7(7):951-63.

Immunoregulatory dendritic cells to prevent and reverse new-onset Type 1 diabetes mellitus.

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  • 1Children's Hospital of Pittsburgh, Diabetes Institute, Pittsburgh, PA 15213, USA.


Herein, the authors provide an overview of where dendritic cells lie in the immunopathology of autoimmune Type 1 diabetes mellitus and how dendritic cell-based therapy may be usefully translated to treat and reverse the disease. The immunopathology of Type 1 diabetes mellitus offers a number of windows at which immunotherapy can be applied to delay, stop and even reverse the autoimmune processes, especially in light of the recent antibody-based accomplishment of improvement in residual beta-cell mass function. As in almost all cell-specific inflammatory processes, dendritic cells are central regulators of diabetes onset and progression. This realisation, along with accumulating data confirming a role for dendritic cells in maintaining and inducing tolerance in multiple therapeutic settings, has prompted a line of investigation to identify the most effective embodiments of dendritic cells for diabetes immunotherapy.

[PubMed - indexed for MEDLINE]
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