Audiol Neurootol. 2007;12(6):345-58. Epub 2007 Jul 27.

The complexity of age-related hearing impairment: contributing environmental and genetic factors.

Source

Department of Medical Genetics, University of Antwerp, Antwerp, Belgium.

Abstract

Age-related hearing impairment (ARHI) is the most common sensory impairment seen in the elderly. It is a complex disorder, with both environmental as well as genetic factors contributing to the impairment. The involvement of several environmental factors has been partially elucidated. A first step towards the identification of the genetic factors has been made, which will result in the identification of susceptibility genes, and will provide possible targets for the future treatment and/or prevention of ARHI. This paper aims to give a broad overview of the scientific findings related to ARHI, focusing mainly on environmental and genetic data in humans and in animal models. In addition, methods for the identification of contributing genetic factors as well as possible future therapeutic strategies are discussed.

PMID:: 17664866; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

DIRAS3 Gene - Genetics Home Reference

Supplemental Content

Related citations

Review Environmental and genetic factors in age-related hearing impairment. [Aging Clin Exp Res. 2011]
Review Environmental and genetic factors in age-related hearing impairment.
Bovo R, Ciorba A, Martini A. Aging Clin Exp Res. 2011 Feb; 23(1):3-10.
A novel Z-score-based method to analyze candidate genes for age-related hearing impairment. [Ear Hear. 2004]
A novel Z-score-based method to analyze candidate genes for age-related hearing impairment.
Fransen E, Van Laer L, Lemkens N, Caethoven G, Flothmann K, Govaerts P, Van de Heyning P, Van Camp G. Ear Hear. 2004 Apr; 25(2):133-41.
Review Age-related hearing impairment (ARHI): environmental risk factors and genetic prospects. [Exp Gerontol. 2003]
Review Age-related hearing impairment (ARHI): environmental risk factors and genetic prospects.
Fransen E, Lemkens N, Van Laer L, Van Camp G. Exp Gerontol. 2003 Apr; 38(4):353-9.
The contribution of family history to hearing loss in an older population. [Ear Hear. 2008]
The contribution of family history to hearing loss in an older population.
McMahon CM, Kifley A, Rochtchina E, Newall P, Mitchell P. Ear Hear. 2008 Aug; 29(4):578-84.
Occupational noise, smoking, and a high body mass index are risk factors for age-related hearing impairment and moderate alcohol consumption is protective: a European population-based multicenter study. [J Assoc Res Otolaryngol. 2008]
Occupational noise, smoking, and a high body mass index are risk factors for age-related hearing impairment and moderate alcohol consumption is protective: a European population-based multicenter study.
Fransen E, Topsakal V, Hendrickx JJ, Van Laer L, Huyghe JR, Van Eyken E, Lemkens N, Hannula S, Mäki-Torkko E, Jensen M, et al. J Assoc Res Otolaryngol. 2008 Sep; 9(3):264-76; discussion 261-3. Epub 2008 Jun 10.

See reviews... See all...

Cited by 9 PubMed Central articles

A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice. [Front Neuroanat. 2010]
A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice.
Riquelme R, Cediel R, Contreras J, la Rosa Lourdes RD, Murillo-Cuesta S, Hernandez-Sanchez C, Zubeldia JM, Cerdan S, Varela-Nieto I. Front Neuroanat. 2010 Jul 13; 4:27. Epub 2010 Jul 13.
Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. [PLoS One. 2010]
Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice.
Noben-Trauth K, Latoche JR, Neely HR, Bennett B. PLoS One. 2010 Jul 7; 5(7):e11459. Epub 2010 Jul 7.
Review Chemical screening for hair cell loss and protection in the zebrafish lateral line. [Zebrafish. 2010]
Review Chemical screening for hair cell loss and protection in the zebrafish lateral line.
Coffin AB, Ou H, Owens KN, Santos F, Simon JA, Rubel EW, Raible DW. Zebrafish. 2010 Mar; 7(1):3-11.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The complexity of age-related hearing impairment: contributing environmental and...
The complexity of age-related hearing impairment: contributing environmental and genetic factors.
Audiol Neurootol. 2007 ;12(6):345-58. Epub 2007 Jul 27 .

PubMed
Special issue on phylogenomics and its future.
Special issue on phylogenomics and its future.
Gene. 2009 Jul 15 ;441(1-2):1-2. Epub 2009 Apr 15 .

PubMed
Myostatin and muscle fiber size. Focus on "Smad2 and 3 transcription factors con...
Myostatin and muscle fiber size. Focus on "Smad2 and 3 transcription factors control muscle mass in adulthood" and "Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size".
Am J Physiol Cell Physiol. 2009 Jun ;296(6):C1245-7. Epub 2009 Apr 8 .

PubMed
Global regulation by (p)ppGpp and CodY in Streptococcus mutans.
Global regulation by (p)ppGpp and CodY in Streptococcus mutans.
J Bacteriol. 2008 Aug ;190(15):5291-9. Epub 2008 Jun 6 .

PubMed
Medulloblastomas and central nervous system primitive neuroectodermal tumors.
Medulloblastomas and central nervous system primitive neuroectodermal tumors.
Curr Treat Options Oncol. 2003 Dec ;4(6):499-508.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

The complexity of age-related hearing impairment: contributing environmental and genetic factors.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Related citations

Cited by 9 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information