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J Vasc Surg. 2007 Aug;46(2):373-386.

Statins: an essential component in the management of carotid artery disease.

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  • 1Department of Clinical Biochemistry, Royal Free Hospital, London, United Kingdom.

Abstract

OBJECTIVE:

We aimed to define the role of treatment using statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) in the management of patients with carotid artery disease.

LITERATURE SEARCH METHODS:

We searched PubMed for studies evaluating the effect of statins on carotid IMT and the occurrence of cerebrovascular events.

LITERATURE SEARCH RESULTS:

Current evidence indicates that routine statin therapy reduces carotid intima-media thickness progression and stroke risk. Additionally, statin treatment significantly reduces perioperative as well as long-term morbidity and mortality in patients undergoing carotid surgery or endovascular interventions. It would also be expected that statins would reduce coronary events in this high-risk population.

CONCLUSIONS:

Statins should be considered as an essential component of the therapeutic approach of patients with carotid artery stenosis.

[PubMed - indexed for MEDLINE]
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