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1: Org Lett. 2007 Aug 30;9(18):3643-5. Epub 2007 Jul 31.Click here to read Links

Self-assembly of a cyclobutane beta-tetrapeptide to form nanosized structures.

Rúa F, Boussert S, Parella T, Díez-Pérez I, Branchadell V, Giralt E, Ortuño RM.

Departament de Química, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

A beta-tetrapeptide made up of homochiral cyclobutane residues displays conformational bias in solution prompted by the formation of intramolecular hydrogen bonds. Moreover, this compound self-assembles to produce nanosized fibrils and, in some media, it also forms a gel. The combination of NMR, TEM, AFM, and theoretical calculations has proven to be very useful in obtaining insight into the details of these new structures.

PMID: 17663562 [PubMed - indexed for MEDLINE]