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    Tissue Antigens. 2007 Sep;70(3):228-32.

    KIR3DL2: diversity in a hematopoietic stem cell transplant population.

    Gedil MA, Steiner NK, Hurley CK.

    Department of Oncology, CW Bill Young Marrow Donor Recruitment and Research Program, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA.

    Exons 2 through 9 of KIR3DL2 were amplified from genomic DNA from 79 bone marrow transplantation patients and their unrelated donors. Sequencing of heterozygotes and isolated alleles identified 9 of the 17 known alleles. The alleles provide confirmation of previously submitted sequences and are carried by transformed B-cell lines that can be used as references for assay development. Alleles 3DL2*001, *002, *007 and *009 accounted for 111 of the total 144 possible alleles and were the only ones found in a homozygous state. New alleles (3DL2*017, *018, *019, *020, and *021) were found in seven transplant samples and one workshop cell. This study describes the development of reagents and protocols for sequencing of KIR3DL2 alleles from genomic DNA.

    PMID: 17661911 [PubMed - indexed for MEDLINE]

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