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Eur J Pain. 2008 Apr;12(3):301-13. Epub 2007 Jul 30.

Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study.

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  • 1Department of Child and Adolescent Psychiatry, University of Heidelberg, Blumenstrasse 8, D-69115 Heidelberg, Germany. rieke_oelkers@med.uni-heidelberg.de

Abstract

BACKGROUND:

Migraine is very common in school-aged children, but despite a number of pharmacological and non-pharmacological options for prophylaxis, randomized controlled evidence in children is small. Evidence-based prophylactic drugs may have considerable side effects.

OBJECTIVE:

This study was to assess efficacy of a butterbur root extract (Petadolex) and music therapy in primary school children with migraine.

DESIGN:

Prospective, randomized, partly double-blind, placebo-controlled, parallel-group trial.

METHODS:

Following a 8-week baseline patients were randomized and received either butterbur root extract (n=19), music therapy (n=20) or placebo (n=19) over 12 weeks. All participants received additionally headache education ("treatment as usual") from the baseline onwards. Reduction of headache frequency after treatment (8-week post-treatment) as well as 6 months later (8-week follow-up) was the efficacy variable.

RESULTS:

Data analysis of subjects completing the respective study phase showed that during post-treatment, only music therapy was superior to placebo (p=0.005), whereas in the follow-up period both music therapy and butterbur root extract were superior to placebo (p=0.018 and p=0.044, respectively). All groups showed a substantial reduction of attack frequency already during baseline.

CONCLUSION:

Butterbur root extract and music therapy might be superior to placebo and may represent promising treatment approaches in the prophylaxis of paediatric migraine.

PMID:
17659990
[PubMed - indexed for MEDLINE]
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