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Genome Biol. 2007;8(7):R144.

High-throughput analysis of spatio-temporal dynamics in Dictyostelium.

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  • 1Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. ssawai@complex.c.u-tokyo.ac.jp

Abstract

We demonstrate a time-lapse video approach that allows rapid examination of the spatio-temporal dynamics of Dictyostelium cell populations. Quantitative information was gathered by sampling life histories of more than 2,000 mutant clones from a large mutagenesis collection. Approximately 4% of the clonal lines showed a mutant phenotype at one stage. Many of these could be ordered by clustering into functional groups. The dataset allows one to search and retrieve movies on a gene-by-gene and phenotype-by-phenotype basis.

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PMID:
17659086
[PubMed - indexed for MEDLINE]
PMCID:
PMC2323234
Free PMC Article

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