Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Cell Biol. 2007 Jul;17(7):318-24. Epub 2007 Jul 19.

The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control.

Author information

  • 1EMBL Mouse Biology Unit, Monterotondo, Italy. nerlov@embl.it <nerlov@embl.it>

Abstract

In recent years, a link between the transcriptional regulators of lineage-specific gene expression and progenitor proliferation control has emerged. A main exponent of this phenomenon is the CCAAT/enhancer binding protein (C/EBP) family of basic region-leucine zipper proteins. These transcription factors control the differentiation of a range of cell types, and have key roles in regulating cellular proliferation through interaction with cell cycle proteins. More recently, their position at the crossroads between proliferation and differentiation has made them strong candidate regulators of tumorigenesis, and C/EBPs have been described as both tumor promoters and tumor suppressors.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk