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Trends Biotechnol. 2007 Sep;25(9):385-9. Epub 2007 Jul 19.

Toward nanoscale genome sequencing.

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  • 1Department of Electrical Engineering, University of Washington Paul Allen Center, AE100R Box 352500 Seattle, WA 98195, USA.


This article reports on the state-of-the-art technologies that sequence DNA using miniaturized devices. The article considers the miniaturization of existing technologies for sequencing DNA and the opportunities for cost reduction that 'on-chip' devices can deliver. The ability to construct nano-scale structures and perform measurements using novel nano-scale effects has provided new opportunities to identify nucleotides directly using physical, and not chemical, methods. The challenges that these technologies need to overcome to provide a US$1000-genome sequencing technology are also presented.

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