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Scand J Rheumatol. 2007 May-Jun;36(3):222-5.

Increased serum levels of macrophage migration inhibitory factor in patients with Kawasaki disease.

Author information

  • 1Department of Paediatrics, Institute for immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.

Abstract

OBJECTIVE:

To determine whether serum levels of macrophage migration inhibitory factor (MIF) increase in patients with Kawasaki disease (KD) and also correlate with other inflammatory indices.

METHODS:

Serum samples from 10 patients with KD, 15 normal healthy subjects, and seven febrile control subjects were assayed for MIF by enzyme-linked immunosorbent assay (ELISA).

RESULTS:

There was a significant increase in the serum levels of MIF in the acute stage of KD [113.06 (range 20.6-157.36) ng/mL] compared with those in the subacute stage [28.11 (8.57-143.48) ng/mL, p<0.01], normal controls [12.95 (8.40-18.67) ng/mL, p<0.001], and febrile controls [36.58 (21.31-59.67) ng/mL, p = 0.01]. The increase in MIF correlated with an increase in interleukin-6 (IL-6) (r = 0.52, p = 0.047).

CONCLUSION:

MIF may be a useful marker in the acute stage of KD and may provide important clues to the pathogenesis of this disease.

PMID:
17657678
[PubMed - indexed for MEDLINE]
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