Send to:

Choose Destination
See comment in PubMed Commons below
Scand J Rheumatol. 2007 May-Jun;36(3):222-5.

Increased serum levels of macrophage migration inhibitory factor in patients with Kawasaki disease.

Author information

  • 1Department of Paediatrics, Institute for immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.



To determine whether serum levels of macrophage migration inhibitory factor (MIF) increase in patients with Kawasaki disease (KD) and also correlate with other inflammatory indices.


Serum samples from 10 patients with KD, 15 normal healthy subjects, and seven febrile control subjects were assayed for MIF by enzyme-linked immunosorbent assay (ELISA).


There was a significant increase in the serum levels of MIF in the acute stage of KD [113.06 (range 20.6-157.36) ng/mL] compared with those in the subacute stage [28.11 (8.57-143.48) ng/mL, p<0.01], normal controls [12.95 (8.40-18.67) ng/mL, p<0.001], and febrile controls [36.58 (21.31-59.67) ng/mL, p = 0.01]. The increase in MIF correlated with an increase in interleukin-6 (IL-6) (r = 0.52, p = 0.047).


MIF may be a useful marker in the acute stage of KD and may provide important clues to the pathogenesis of this disease.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Write to the Help Desk