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Curr Opin Immunol. 2007 Aug;19(4):408-15. Epub 2007 Jul 25.

CD8 T cell dysfunction during chronic viral infection.

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  • 1Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.


Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.

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