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J Org Chem. 2007 Aug 17;72(17):6628-30. Epub 2007 Jul 27.

Ph3As-catalyzed wittig-type olefination of aldehydes with diazoacetate in the presence of Na2S2O4.

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  • 1State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.


In the presence of sodium hydrosulfite and a catalytic amount of AsPh3 and Fe(TCP)Cl, aldehydes react with ethyl diazoacetate to give the corresponding alpha,beta-unsaturated esters in high yields with excellent stereoselectivities (E/Z > 50/1).

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