Nat Prod Rep. 2007 Aug;24(4):869-85. Epub 2007 Apr 2.

Synthesis of macrocyclic shellfish toxins containing spiroimine moieties.

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Department of Chemistry, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.

Abstract

An overview of the structure and biological activity of macrocyclic polyketides derived from dinoflagellates that contain unusual cyclic imine units is provided. The total and partial syntheses of these molecules are discussed with an emphasis on the construction of the spiroimine functionality thought to be the key pharmacophore of these fact-acting shellfish toxins.

PMID:: 17653363; [PubMed - indexed for MEDLINE]

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