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Kidney Int. 2007 Aug;72(3):237-9.

Vitamin D receptor: a highly versatile nuclear receptor.

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  • 1Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois 60612-7230, USA.


Vitamin D receptor (VDR) modulators are used to treat hyperparathyroidism secondary to chronic kidney disease (CKD). The therapy is associated with reduced mortality in stage 5 CKD patients, who experience an extremely high cardiovascular disease (CVD)-related mortality rate. Chen et al. report that VDR is involved in regulating type A natriuretic peptide receptor (NPR-A) in inner medullary collecting duct cells. The regulation of NPR-A may be one of several mechanisms by which VDR activation reduces CVD risk in CKD.

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