Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuroradiology. 2007 Sep;49(9):703-13. Epub 2007 Jul 24.

MR angiography in the follow-up of intracranial aneurysms treated with Guglielmi detachable coils: systematic review and meta-analysis.

Author information

  • 1Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands. thomaskwee@gmail.com

Abstract

INTRODUCTION:

The aim of this study was to systematically review published data on the diagnostic performance of magnetic resonance angiography (MRA) compared with digital subtraction angiography as reference standard in the follow-up of intracranial aneurysms treated with Guglielmi detachable coils.

METHODS:

A systematic search for relevant studies was performed of the PubMed/MEDLINE and Embase databases. Two reviewers independently assessed the methodological quality of each study. A meta-analysis of the reported sensitivity and specificity of each study was performed.

RESULTS:

The inclusion criteria were met by 16 studies. The studies had moderate methodological quality. Pooled sensitivity and specificity of non-enhanced time-of-flight MRA (TOF-MRA) for the detection of residual flow (within the aneurysmal neck and/or coil mesh) were 83.3% (95% CI 70.3-91.3%) and 90.6% (95% CI 80.4-95.8%), respectively. Pooled sensitivity and specificity of contrast-enhanced MRA (CE-MRA) for the detection of residual flow were 86.8% (95% CI 71.4-94.5%) and 91.9% (95% CI 79.8-97.0%), respectively. All pooled estimates were subject to heterogeneity. There were no statistically significant differences in pooled sensitivity and specificity between TOF-MRA and CE-MRA.

CONCLUSION:

The results of this study suggest that both TOF-MRA and CE-MRA achieve a moderate to high diagnostic performance. However, the findings should be interpreted with caution because the included studies were of moderate methodological quality and all pooled estimates were subject to heterogeneity. More well-designed studies are required to confirm the current results and MRA at higher field strength (>1.5 T) needs to be further explored.

Comment in

PMID:
17646977
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk