Soc Reprod Fertil Suppl. 2007;65:245-59.

Signalling pathways involved in sperm capacitation.

Salicioni AM, Platt MD, Wertheimer EV, Arcelay E, Allaire A, Sosnik J, Visconti PE.

Source

Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA.

Abstract

After ejaculation, mammalian sperm have not yet acquired full fertilising capacity. They will require a finite period of residence in the female reproductive tract before they become fertilisation competent. The molecular, biochemical, and physiological changes that occur to sperm while in the female tract are collectively referred to as capacitation. During capacitation, changes in membrane properties, enzyme activities, and motility render spermatozoa responsive to stimuli that induce the acrosome reaction and prepare spermatozoa for penetration of the egg investments prior to fertilisation. These changes are facilitated by the activation of cell signalling cascades in the female reproductive tract in vivo or in defined media in vitro. The purposes of this review are to consider some recent contributions towards our understanding of capacitation, to summarise open questions in this field, and to discuss future avenues of research.

PMID:: 17644966; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Seminal Plasma Proteins

Grant Support

Supplemental Content

Save items

Related citations in PubMed

Review Intracellular events and signaling pathways involved in sperm acquisition of fertilizing capacity and acrosome reaction. [Front Biosci. 2000]
Review Intracellular events and signaling pathways involved in sperm acquisition of fertilizing capacity and acrosome reaction.
Baldi E, Luconi M, Bonaccorsi L, Muratori M, Forti G. Front Biosci. 2000 Nov 1; 5:E110-23. Epub 2000 Nov 1.
Review Human sperm activation during capacitation and acrosome reaction: role of calcium, protein phosphorylation and lipid remodelling pathways. [Front Biosci. 1996]
Review Human sperm activation during capacitation and acrosome reaction: role of calcium, protein phosphorylation and lipid remodelling pathways.
Baldi E, Luconi M, Bonaccorsi L, Krausz C, Forti G. Front Biosci. 1996 Aug 15; 1:d189-205. Epub 1996 Aug 15.
Review Mammalian sperm capacitation: role of phosphotyrosine proteins. [Soc Reprod Fertil Suppl. 2007]
Review Mammalian sperm capacitation: role of phosphotyrosine proteins.
Shivaji S, Kumar V, Mitra K, Jha KN. Soc Reprod Fertil Suppl. 2007; 63:295-312.
Seminal plasma proteins reduce protein tyrosine phosphorylation in the plasma membrane of cold-shocked ram spermatozoa. [Mol Reprod Dev. 2002]
Seminal plasma proteins reduce protein tyrosine phosphorylation in the plasma membrane of cold-shocked ram spermatozoa.
Pérez-Pé R, Grasa P, Fernández-Juan M, Peleato ML, Cebrián-Pérez JA, Muiño-Blanco T. Mol Reprod Dev. 2002 Feb; 61(2):226-33.
Review Role of signaling pathways in regulating the capacitation of mammalian spermatozoa. [Cell Mol Biol (Noisy-le-grand)...]
Review Role of signaling pathways in regulating the capacitation of mammalian spermatozoa.
Jha KN, Kameshwari DB, Shivaji S. Cell Mol Biol (Noisy-le-grand). 2003 May; 49(3):329-40.

See reviews... See all...

Cited by 11 PubMed Central articles

Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function. [Proc Natl Acad Sci U S A. 2011]
Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function.
Gibbs GM, Orta G, Reddy T, Koppers AJ, Martínez-López P, Luis de la Vega-Beltràn J, Lo JC, Veldhuis N, Jamsai D, McIntyre P, et al. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7034-9. Epub 2011 Apr 11.
Reduced fertility in vitro in mice lacking the cystatin CRES (cystatin-related epididymal spermatogenic): rescue by exposure of spermatozoa to dibutyryl cAMP and isobutylmethylxanthine. [Biol Reprod. 2011]
Reduced fertility in vitro in mice lacking the cystatin CRES (cystatin-related epididymal spermatogenic): rescue by exposure of spermatozoa to dibutyryl cAMP and isobutylmethylxanthine.
Chau KM, Cornwall GA. Biol Reprod. 2011 Jan; 84(1):140-52. Epub 2010 Sep 1.
Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice. [J Clin Invest. 2010]
Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice.
Escoffier J, Jemel I, Tanemoto A, Taketomi Y, Payre C, Coatrieux C, Sato H, Yamamoto K, Masuda S, Pernet-Gallay K, et al. J Clin Invest. 2010 May; 120(5):1415-28. Epub 2010 Apr 26.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Signalling pathways involved in sperm capacitation.
Signalling pathways involved in sperm capacitation.
Soc Reprod Fertil Suppl. 2007 ;65:245-59.

PubMed
Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in h...
Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages.
J Lipid Res. 2007 Oct ;48(10):2112-22. Epub 2007 Jul 20 .

PubMed
Dynamic organization of the emotional brain: responsivity, stability, and instab...
Dynamic organization of the emotional brain: responsivity, stability, and instability.
Neuroscientist. 2007 Aug ;13(4):349-70.

PubMed
High sensitivity detection of plasma proteins by multiple reaction monitoring of...
High sensitivity detection of plasma proteins by multiple reaction monitoring of N-glycosites.
Mol Cell Proteomics. 2007 Oct ;6(10):1809-17. Epub 2007 Jul 20 .

PubMed
A synthetic polypeptide based on human E-cadherin inhibits invasion of human int...
A synthetic polypeptide based on human E-cadherin inhibits invasion of human intestinal and liver cell lines by Listeria monocytogenes.
J Med Microbiol. 2007 Aug ;56(Pt 8):1011-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: