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    Int J Infect Dis. 2008 Jan;12(1):3-11. Epub 2007 Jul 20.

    The underestimated risk of hepatitis A and hepatitis B: benefits of an accelerated vaccination schedule.

    Keystone JS, Hershey JH.

    Source

    Division of Infectious Disease, Department of Medicine, Tropical Disease Unit, Toronto General Hospital, University of Toronto, Toronto, Ontario M5G 2C4, Canada. jay.keystone@utoronto.ca

    Abstract

    Hepatitis A virus (HAV) and hepatitis B virus (HBV) are vaccine-preventable. Current recommendations advocate vaccination of non-immune adults at risk of exposure, including travelers to HAV or HBV endemic areas, individuals with high risk of contracting a sexually transmitted infection, and some correctional facility inmates. We review the use of an accelerated schedule to administer the combination hepatitis A and hepatitis B vaccine (Twinrix). Administering three doses over three weeks and a fourth at 12 months provides rapid initial protection of most individuals for whom the standard 6-month vaccination schedule would not be suitable, including last-minute travelers and short-term correctional facility inmates. Furthermore, we consider the role of a universal vaccination strategy in preventing the spread of HAV and HBV.

    PMID:
    17643334
    [PubMed - indexed for MEDLINE]

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