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Biol Blood Marrow Transplant. 2007 Aug;13(8):886-8. Epub 2007 Jun 18.

Hematopoietic cell transplantation directly into dystrophic muscle fails to reconstitute satellite cells and myofibers.

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  • 1Clinical Research Division, Fred Hutchinson Cancer Research Center, and Department of Surgery, University of Washington School of Medicine, Seattle, Washington 98101, USA.


We sought to determine whether wild-type hematopoietic cell transplantation directly into muscle could restore dystrophin expression in a relevant preclinical canine model of Duchenne muscular dystrophy. In recipients rendered tolerant to their dog leukocyte antigen-matched unaffected littermates through hematopoietic stem cell transplantation, intramuscular injection of donor marrow cells produced no evidence of dystrophin expression, and clonal analysis of satellite cells failed to reveal any donor contribution.

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