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    Biochem J. 1991 Dec 15;280 ( Pt 3):821-4.

    Identification of bile acid-CoA: amino acid N-acyltransferase in rat kidney.

    Kwakye JB, Johnson MR, Barnes S, Grizzle WE, Diasio RB.

    Source

    Department of Pharmacology, University of Alabama, Birmingham 35294.

    Abstract

    A novel location of the bile-acid-conjugating enzyme bile acid-CoA:amino acid N-acyltransferase (BAT) has been discovered in the cytosolic fraction of rat kidney. Both taurine and glycine were utilized as substrates. Formation of bile acid N-acyl amidates was verified by h.p.l.c. by comparison with authentic standards and by specific hydrolysis using cholylglycine hydrolase. Immunoblot analysis using a human liver anti-BAT polyclonal antibody indicated that rat kidney BAT has the same molecular mass as rat liver BAT. These findings suggest that the kidney has a role in bile acid metabolism and physiology.

    PMID:
    1764044
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1130530
    Free PMC Article

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