Send to:

Choose Destination
See comment in PubMed Commons below
Genes Dev. 2007 Jul 15;21(14):1726-30.

Increased association of telomerase with short telomeres in yeast.

Author information

  • 1Department of Molecular Biology and National Centre of Competence in Research (NCCR) Frontiers in Genetics Program, University of Geneva, Sciences III, CH-1211 Geneva 4, Switzerland.


Telomere function is mediated by the assembly of a protein complex on an array of telomeric DNA (TG) repeats synthesized by the telomerase enzyme. Telomerase action at chromosome ends is finely tuned by the telomeric complex so that a constant average number of repeats is maintained. This is achieved through a negative feedback process that is sensitive to TG tract length, but whose underlying mechanism is unknown. We show that short telomeres, which are preferential substrates for telomerase, display increased association with the enzyme in the S phase of the cell cycle, when telomerase acts. In addition, we provide support for a molecular mechanism by which this key step of telomerase recruitment is regulated by TG tract length.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk