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Nat Chem Biol. 2007 Aug;3(8):442-6.

Scaffold composition and biological relevance of screening libraries.

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  • 1Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38103, USA.


The chemical scaffolds from which screening libraries are built have strong influence on the libraries' utility for screening campaigns. Here we present analysis of the scaffold composition of several types of commercially available screening collections and compare those compositions to those of drugs and drug candidates.

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