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J Am Acad Dermatol. 2007 Oct;57(4):588-93. Epub 2007 Jul 16.

Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: the effect of UVB dose and skin color.

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  • 1Creighton University Medical Center, Omaha, Nebraska 68131, USA. larmas@creighton.edu

Abstract

BACKGROUND:

Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized.

OBJECTIVE:

We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation.

METHODS:

Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly.

RESULTS:

Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning.

LIMITATIONS:

Four weeks was not long enough to reach a steady state at the higher dose rates.

CONCLUSIONS:

The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.

Comment in

PMID:
17637484
[PubMed - indexed for MEDLINE]
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