Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB

J Am Chem Soc. 2007 Aug 8;129(31):9613-5. doi: 10.1021/ja0727520. Epub 2007 Jul 18.

Authors

Matthew B Soellner¹, Katherine A Rawls, Christoph Grundner, Tom Alber, Jonathan A Ellman

Affiliation

¹ Department of Chemistry, University of California, Berkeley, California 94720, USA.

PMID: 17636914
DOI: 10.1021/ja0727520

No abstract available

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Biphenyl Compounds / chemistry
Drug Evaluation, Preclinical / methods*
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology*
Molecular Structure
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / enzymology*
Phosphates / chemistry
Phosphates / metabolism
Phosphoric Monoester Hydrolases / antagonists & inhibitors*
Phosphoric Monoester Hydrolases / metabolism*
Protein-Tyrosine Kinases / antagonists & inhibitors
Protein-Tyrosine Kinases / metabolism
Spectrophotometry
Structure-Activity Relationship
Substrate Specificity

Substances

Biphenyl Compounds
Enzyme Inhibitors
Phosphates
diphenyl
Protein-Tyrosine Kinases
Phosphoric Monoester Hydrolases

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