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Biochem Biophys Res Commun. 2007 Sep 14;361(1):1-6. Epub 2007 Jul 2.

Expression of GATA-3 in epidermis and hair follicle: relationship to p63.

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  • 1Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, via di Tor Vergata 135, 00133 Rome, Italy.

Abstract

The epidermis is a multi-layered stratified epithelium continuously renewed by differentiating keratinocytes that develops by the action of p63, a member of the p53 family. The TP63 contains two promoters, resulting in the expression of different proteins, containing (TAp63) or not (DeltaNp63) an amino-terminal transactivation domain, which contribution in skin formation is not fully understood. We found that p63 binds and transactivate GATA-3 promoter, which in turn transactivate IKKalpha, two pivotal regulators of epithelial development. Indeed, GATA-3 is a regulator of cell lineage in skin and hair follicles formation. To further study the relationship between GATA-3 and p63 isoforms here we investigated their expression during keratinocyte differentiation, in human epidermis and hair follicle.

PMID:
17632082
[PubMed - indexed for MEDLINE]
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