Cell. 2007 Jul 13;130(1):25-35.

Multistep pathogenesis of autoimmune disease.

Source

John Curtin School of Medical Research and Australian Phenomics Facility, The Australian National University, Canberra ACT 2601, Australia. chris.goodnow@anu.edu.au

Abstract

In the immune system, many tolerance checkpoints exist to prevent self-antigens from stimulating the relentless growth of self-reactive B and T lymphocytes. The genes and molecular pathways underpinning these checkpoints overlap with those involved in tumor suppression. As with an inherited predisposition to cancer, inherited defects in self-tolerance genes typically precipitate autoimmune disease stochastically after a latent phase. Multiple mutations, inherited and somatic, may be needed before a self-reactive clone bypasses sequential tolerance checkpoints resulting in the emergence of autoimmune disease.

Comment in

Cell. 2007 Dec 28;131(7):1220-1.

PMID:: 17632054; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Breakdown of self-tolerance and the pathogenesis of autoimmunity. [Semin Nephrol. 1999]
Review Breakdown of self-tolerance and the pathogenesis of autoimmunity.
Ring GH, Lakkis FG. Semin Nephrol. 1999 Jan; 19(1):25-33.
Review Autoimmunity and apoptosis--therapeutic implications. [Curr Med Chem. 2007]
Review Autoimmunity and apoptosis--therapeutic implications.
Rashedi I, Panigrahi S, Ezzati P, Ghavami S, Los M. Curr Med Chem. 2007; 14(29):3139-51.
Review Primer: mechanisms of immunologic tolerance. [Nat Clin Pract Rheumatol. 2006]
Review Primer: mechanisms of immunologic tolerance.
Singh NJ, Schwartz RH. Nat Clin Pract Rheumatol. 2006 Jan; 2(1):44-52.
Review How the immune system achieves self-nonself discrimination during adaptive immunity. [Adv Immunol. 2009]
Review How the immune system achieves self-nonself discrimination during adaptive immunity.
Jiang H, Chess L. Adv Immunol. 2009; 102:95-133.
Review Pathways for self-tolerance and the treatment of autoimmune diseases. [Lancet. 2001]
Review Pathways for self-tolerance and the treatment of autoimmune diseases.
Goodnow CC. Lancet. 2001 Jun 30; 357(9274):2115-21.

See reviews... See all...

Cited by 42 PubMed Central articles

Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity. [Proc Natl Acad Sci U S A. 2012]
Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity.
Larson JD, Thurman JM, Rubtsov AV, Claypool D, Marrack P, van Dyk LF, Torres RM, Pelanda R. Proc Natl Acad Sci U S A. 2012 May 1; 109(18):E1092-100. Epub 2012 Apr 2.
Genetic association and altered gene expression of mir-155 in multiple sclerosis patients. [Int J Mol Sci. 2011]
Genetic association and altered gene expression of mir-155 in multiple sclerosis patients.
Paraboschi EM, Soldà G, Gemmati D, Orioli E, Zeri G, Benedetti MD, Salviati A, Barizzone N, Leone M, Duga S, et al. Int J Mol Sci. 2011; 12(12):8695-712. Epub 2011 Dec 1.
Loss of Roquin induces early death and immune deregulation but not autoimmunity. [J Exp Med. 2011]
Loss of Roquin induces early death and immune deregulation but not autoimmunity.
Bertossi A, Aichinger M, Sansonetti P, Lech M, Neff F, Pal M, Wunderlich FT, Anders HJ, Klein L, Schmidt-Supprian M. J Exp Med. 2011 Aug 29; 208(9):1749-56. Epub 2011 Aug 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Multistep pathogenesis of autoimmune disease.
Multistep pathogenesis of autoimmune disease.
Cell. 2007 Jul 13 ;130(1):25-35.

PubMed
The "minimal self" in psychopathology: re-examining the self-disorders in the sc...
The "minimal self" in psychopathology: re-examining the self-disorders in the schizophrenia spectrum.
Conscious Cogn. 2007 Sep ;16(3):703-14. Epub 2007 Jul 13 .

PubMed
Elastin as a biomaterial for tissue engineering.
Elastin as a biomaterial for tissue engineering.
Biomaterials. 2007 Oct ;28(30):4378-98. Epub 2007 Jul 12 .

PubMed
Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunit...
Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb+ efflux with high and low sensitivity to stimulation by acetylcholine.
Neuropharmacology. 2007 Sep ;53(3):390-405. Epub 2007 Jun 7 .

PubMed
Cells isolated from trypsin-treated brain contain trypsin.
Cells isolated from trypsin-treated brain contain trypsin.
J Neurochem. 1976 Jan ;26(1):41-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Multistep pathogenesis of autoimmune disease.

Source

Abstract

Comment in

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 42 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information