A new approach for 'deep salvage' trials in advanced HIV infection

AIDS. 2007 Jul 31;21(12):1503-6. doi: 10.1097/QAD.0b013e3281338384.

Abstract

One of the most difficult problems in HIV care today is the management of individuals infected with multidrug-resistant viruses. Well-controlled, carefully designed clinical trials have recently resulted in the approval of several new antiviral agents for the treatment of drug-resistant HIV. The design of these trials has come at the cost of the predictable emergence of drug-resistant viruses among individuals randomly assigned to receive a suboptimal revised treatment regimen. We propose here a different approach to the evaluation of drug efficacy in individuals harbouring multidrug-resistant HIV.

Publication types

  • Review

MeSH terms

  • Anti-HIV Agents / therapeutic use*
  • Clinical Trials as Topic / methods*
  • Drug Resistance, Multiple, Viral
  • HIV Infections / drug therapy*
  • Humans
  • Research Design
  • Salvage Therapy / methods*

Substances

  • Anti-HIV Agents