Arthritis Res Ther. 2007;9(4):105.

Dysautonomia, fibromyalgia and reflex dystrophy.

Abstract

Autonomic nervous system dysfunction observed in fibromyalgia, characterized without exception by a sympathetic hyperactivity and hyporeactivity, has been reported. However, several studies demonstrated reduced levels of norepinephrine and neuropeptide Y at rest and after tilt table in some patients, which was improved by beta-stimulating agents. These findings support heterogeneity in fibromyalgia-associated dysautonomia. Fibromyalgia could be a generalized sympathetic dystrophy since both conditions are activated by trauma and partly linked to sympathetic mechanisms. Yet they differ on several points: hormonal and neurochemical abnormalities are observed in fibromyalgia whereas activation by peripheral trauma and hyperosteolysis are observed in reflex sympathetic dystrophy.

Comment in

Arthritis Res Ther. 2008;10(6):408; author reply 409.

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Arthritis Res Ther. 2007;9(4):216.

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PMCID:: PMC2206362

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Cited by 1 PubMed Central article

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