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Dev Genes Evol. 2007 Aug;217(8):613-8. Epub 2007 Jul 12.

Evolution of the Groucho/Tle gene family: gene organization and duplication events.

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  • 1Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria. bajoghli@immunbio.mpg.de

Abstract

The Groucho/Tle family of corepressor proteins has important roles in development and in adult tissue in both Protostomes and Deuterostomes. In Drosophila, a single member of this family has been identified. Unlike in Protostomes, most Deutrostomes contain more than two full-length Tle genes. In this study, I analyse the genomic organization and phylogenetic relationship between the long and short forms of the Groucho/Tle family members in Chordata. The genomic location and sequence similarities suggest that Aes/Grg5 and Tle6/Grg6 arose from duplication of the Tle2 gene; each evolved independently and acquired new functions as negative regulators of the other Tle proteins. Based on these data, a model for Groucho/Tle gene evolution is proposed.

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