Send to

Choose Destination
See comment in PubMed Commons below
Dement Geriatr Cogn Disord. 2007;24(2):118-24. Epub 2007 Jul 2.

Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly.

Author information

  • 1Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, University Hospital MAS, Malmo, Sweden.



To investigate whether cerebrospinal fluid (CSF) biomarkers can predict cognitive decline in healthy, elderly individuals as they have been shown to do in cognitively impaired patient samples.


In this study, 57 controls were tested for CSF biomarkers at baseline and then cognitively followed over 3 years.


Low levels of baseline beta-amyloid 1-42 (Abeta42) were associated with development of subjective memory impairment affecting quality of life (memQoL), with a worse Mini Mental Status Examination score and with inability to live in regular housing at follow-up (p < 0.05). The combination of baseline Abeta42 and phosphorylated tau (P-tau) was found to predict development of pathological memQoL with a sensitivity of 71.4% and a specificity of 75.7 (<0.01).


Low Abeta42 and combined Abeta42 and P-tau predicted subjective cognitive decline in healthy individuals. In summary, this study shows that already in the clinically normal population Alzheimer-disease-related biological signs might be detectable.

(c) 2007 S. Karger AG, Basel.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Write to the Help Desk