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Exerc Sport Sci Rev. 2007 Jul;35(3):97-101.

Transcriptional control of the Pgc-1alpha gene in skeletal muscle in vivo.

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  • 1Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA.


Endurance exercise promotes mitochondrial biogenesis in skeletal muscle possibly by inducing peroxisome proliferator-activated receptor gamma coactivator 1alpha gene transcription through activation of the p38 mitogen-activated protein kinase pathway. A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1alpha gene in skeletal muscle in vivo.

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