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Antimicrob Agents Chemother. 2007 Sep;51(9):3445-8. Epub 2007 Jul 9.

Characterization of a daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus strain in a patient with endocarditis.

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  • 1Penn State Milton S. Hershey Medical Center, Room C6833, BMR Bldg., Mailcode H036, 500 University Dr., Hershey, PA 17033, USA.


We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid O-acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene.

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