ScientificWorldJournal. 2007 May 29;7:666-85.

The physiology of obese-hyperglycemic mice [ob/ob mice].

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Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umeå University, Umeå, Sweden. per.lindstrom@histocel.umu.se

Abstract

This review summarizes key aspects of what has been learned about the physiology of leptin deficiency as it can be observed in obese-hyperglycemic ob/ob mice. These mice lack functional leptin. They are grossly overweight and hyperphagic, particularly at young ages, and develop severe insulin resistance. They have been used as a model for obesity and as a rich source of pancreatic islets with high insulin release capacity. The leptin deficiency manifests also with regard to immune function, the cardiovascular system including angiogenesis, supportive tissue function, malignancies, and reproductive function. ob/ob Mice are well suited for studies on the interaction between leptin and insulin, and for studies on initial aspects of metabolic disturbances leading to type-2 diabetes.

PMID:: 17619751; [PubMed - indexed for MEDLINE]

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Cited by 11 PubMed Central articles

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Kosacka J, Nowicki M, Klöting N, Kern M, Stumvoll M, Bechmann I, Serke H, Blüher M. PLoS One. 2012; 7(3):e32881. Epub 2012 Mar 6.
Identification of 9-cis-retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretion. [Proc Natl Acad Sci U S A. 2010]
Identification of 9-cis-retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretion.
Kane MA, Folias AE, Pingitore A, Perri M, Obrochta KM, Krois CR, Cione E, Ryu JY, Napoli JL. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21884-9. Epub 2010 Nov 29.
CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor. [Am J Physiol Regul Integr Comp...]
CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor.
Bradford EM, Miller ML, Prasad V, Nieman ML, Gawenis LR, Berryman M, Lorenz JN, Tso P, Shull GE. Am J Physiol Regul Integr Comp Physiol. 2010 Jun; 298(6):R1531-42. Epub 2010 Mar 31.

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