Nat Genet. 2007 Aug;39(8):954-6. Epub 2007 Jul 8.

A common genetic risk factor for colorectal and prostate cancer.

Haiman CA, Le Marchand L, Yamamato J, Stram DO, Sheng X, Kolonel LN, Wu AH, Reich D, Henderson BE.

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Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA. haiman@usc.edu

Abstract

Variants on chromosome 8q24 contribute risk for prostate cancer; here, we tested whether they also modulate risk for colorectal cancer. We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22; P = 4.4 x 10(-6)) and that the apportionment of risk among the variants differs significantly between the two cancers. Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type.

PMID:: 17618282; [PubMed - indexed for MEDLINE]
PMCID:: PMC2391283

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