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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Sep;104(3):e15-25. Epub 2007 Jul 6.

Sinus floor elevation using autogenous bone or bone substitute combined with platelet-rich plasma.

Author information

  • 1Department of Oral Maxillofacial Surgery, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany. andreas.schlegel@yahoo.de

Abstract

OBJECTIVE:

Sinus augmentation is a common approach for patients with severe alveolar ridge atrophy. However, autogenous bone sometimes results in donor site complications. Bone substitutes with platelet-rich plasma (PRP) promote early bone formation with autogenous bone. Use of PRP on autogenous bone and a bovine bone substitute were investigated in this split-mouth animal study.

STUDY DESIGN:

Premolars were extracted from minipigs. Each animal received sinus augmentation using a lateral approach with simultaneous insertion of 3 implants in each site. Groups were randomized using autogenous bone alone and combined with PRP or a bovine hydroxyapatite alone in combination with PRP.

RESULTS:

Microradiographic findings in the autogenous group did not show significantly different rates by using autogenous bone alone or combined with PRP. Using the bovine hydroxyapatite as augmentation material only at 8 weeks, a nonsignificant effect in the PRP group could be seen. At all other observation periods, no significant influence was observed.

CONCLUSION:

No significant influence of PRP was found.

PMID:
17618141
[PubMed - indexed for MEDLINE]
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