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1: Cancer Res. 2007 Jul 1;67(13):6003-6.Click here to read Links

The role of vascular cell adhesion molecule-1 in tumor immune evasion.

Wu TC.

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA. wutc@jhmi.edu

Tumor immune escape is a critical trait of cancer but the mechanisms involved have yet to fully emerge. One recent study has shown that tumor cells can escape T-cell immunity by overexpressing the endothelial cell adhesion molecule vascular cell adhesion molecule-1 (VCAM-1), which normally mediates leukocyte extravasion to sites of tissue inflammation. Renal cell carcinoma (RCC) was identified as one tumor type where VCAM-1 is commonly highly overexpressed. Together, our findings suggest that RCCs might exploit VCAM-1 overexpression for immune escape.

PMID: 17616653 [PubMed - indexed for MEDLINE]