Format

Send to:

Choose Destination
See comment in PubMed Commons below
Eukaryot Cell. 2007 Sep;6(9):1656-64. Epub 2007 Jul 6.

Histone deacetylase activity regulates chemical diversity in Aspergillus.

Author information

  • 1Plant Pathology Department, Russell Laboratories, University of Wisconsin--Madison, 1630 Linden Drive, Madison, WI 53706, USA.

Abstract

Bioactive small molecules are critical in Aspergillus species during their development and interaction with other organisms. Genes dedicated to their production are encoded in clusters that can be located throughout the genome. We show that deletion of hdaA, encoding an Aspergillus nidulans histone deacetylase (HDAC), causes transcriptional activation of two telomere-proximal gene clusters--and subsequent increased levels of the corresponding molecules (toxin and antibiotic)--but not of a telomere-distal cluster. Introduction of two additional HDAC mutant alleles in a DeltahdaA background had minimal effects on expression of the two HdaA-regulated clusters. Treatment of other fungal genera with HDAC inhibitors resulted in overproduction of several metabolites, suggesting a conserved mechanism of HDAC repression of some secondary-metabolite gene clusters. Chromatin regulation of small-molecule gene clusters may enable filamentous fungi to successfully exploit environmental resources by modifying chemical diversity.

PMID:
17616629
[PubMed - indexed for MEDLINE]
PMCID:
PMC2043372
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk