Science. 2007 Aug 10;317(5839):819-23. Epub 2007 Jul 5.

High-speed imaging reveals neurophysiological links to behavior in an animal model of depression.

Airan RD, Meltzer LA, Roy M, Gong Y, Chen H, Deisseroth K.

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Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

Abstract

The hippocampus is one of several brain areas thought to play a central role in affective behaviors, but the underlying local network dynamics are not understood. We used quantitative voltage-sensitive dye imaging to probe hippocampal dynamics with millisecond resolution in brain slices after bidirectional modulation of affective state in rat models of depression. We found that a simple measure of real-time activity-stimulus-evoked percolation of activity through the dentate gyrus relative to the hippocampal output subfield-accounted for induced changes in animal behavior independent of the underlying mechanism of action of the treatments. Our results define a circuit-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms.

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Science. 2007 Aug 10;317(5839):757-8.

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High-speed imaging reveals neurophysiological links to behavior in an animal model of depression.

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